Frasier and Martin argue over whether Martin can bring another pet into the household, and the doctor finally relents to letting his father have a turtle as long as it stays in a terrarium. Over the next few days, Frasier begins stumbling upon Martin’s turtle in his bathtub, sock drawers, kitchen cupboards, grand piano, mattress and just about everywhere he can think to look. Martin pleads innocent with an exaggerated shrug, and several turtles fall out of his shirt sleeves. Roz dates a man who keeps sending her exotic flowers that she is highly allergic to, but finds the gesture so sweet she is unable to dump him. He finally breaks things off due to her swollen, reddish and mucous appearance. Niles awakens to find his apartment crawling with vines, but soon he and Daphne begin to embrace their primal nature, swinging blissfully from the mysterious foliage as they travel from room to room, gathering the proliferative tropical fruit that now seems to grow everywhere. After a few days go by, Niles - now clad in a finely tailored loincloth - notices he can no longer tell where the walls of his apartment are and can walk for miles in any direction without undue obstruction. Finding his way back proves a different matter altogether.
Martin attempts to eat a 60 oz steak and succeeds. Niles plays chess with a grandmaster and finds that whenever he places a hand on one of the pieces, he can hear the man’s voice in his head. Every time Niles goes to make a strategically sound move, he is deterred from that option by the grandmaster’s voice threatening to kill him and his loved ones. Daphne and Freddie spend an afternoon watching zombie movies in Frasier’s condo. When the bloated, shambling, blood-smeared and moaning Martin shuffles through the door, a jumpy Daphne bashes in his skull with a piece of African art. Frasier notices his own cranium visibly pulsates when he is deep in thought. After a particularly insightful and articulate rant on his radio show, a loud boom echoes through the station. Roz sits gaping in horror as a totally new, naked Frasier emerges from the gory wreckage of the dead Frasier’s burst skull.
Tired of being mocked by both his father and the farm-reared Wisconite Roz for his pampered, city-slicking ways, Frasier drags the pair - along with Niles, Daphne and Eddie - on a camping trip in Martin’s Winnebago. On the first evening, the boastful radio shrink asserts that his medical training has provided him with many useful wilderness skills, such as the ability to suck the venom from a snakebite, but Martin and the others remain comically dismissive of his claims. Later that night after the others have gone to bed, a furious Frasier sneaks a large poisonous snake into the camper in a desperate ploy to prove himself.
Daphne and Niles go out for a hike and a picnic the next day. While they eat, Niles’ selection of strong cheeses and red wine attracts scores of surprisingly aggressive ants which eventually carry the effete doctor off into the woods. Daphne follows half-heartedly for a short time, then shrugs and returns to the Winnebago, where she finds Martin and Frasier franticly arguing over a shallow, hastily-dug grave, with a bloated corpse wrapped in a dirty white sheet lying next to the excavation and no sign of Roz.
Niles begins dictating notes on patient files to his secretary at work after developing severe carpal tunnel syndrome. Roz overhears a shawl-and-sunglass-clad Daphne talking to someone at Nervosa in a perfectly clean American accent. Frasier becomes convinced he is the only one who can see Martin. When Niles opens his secretary’s notebook to refer to during a session, he finds it filled with doodles of a caricature of himself being violently maimed and killed in increasingly savage ways.
Frasier is granted Spectre status by the Council, but his ruthless and uncompromising tactics soon make him more of a liability to galactic safety than anybody he was tasked with bringing down. Niles starts earning credits under the table by selling his patients’ confidential psychiatric files to the Shadow Broker, all unbeknownst to Maris, who refuses to leave her bedroom without the protection of an ostentatious quarian envirosuit. After KACL upgrades their radio consoles, Roz’ electronics skill proves too low to operate them. She takes a job as an exotic dancer in Chora’s Den and is eventually sold to batarian slavers. Daphne dates a high-priced volus lawyer named Don Niduglas, whose diminutive stature is made up for by his confidence, power and intellect. Spending an evening stargazing with his new telescope, Martin spies a Geth incursion in the Hades-Gamma cluster, but is frustrated when no one will believe him.
Eddie’s incessant barking drives Frasier to constantly play the most bombastic operas in his collection at absurd volumes so that he won’t have to listen to the dog’s racket, but his plan backfires when he slowly begins to go deaf from exposure to the ludicrous cacophony. Later on his show, unable to hear a word from any of his callers, Frasier thinks he has dead air and is thus only speaking to Roz when he begins to lampoon the station’s management, the people of Seattle and several completely unrelated sacred cows such as women’s suffrage, race and homosexuality.
En route home from his favourite chili stand, Martin suffers from horrible gas. After a passing TV executive observes Martin’s unabashed flatulence, Martin finds himself starring as “Fartin’ Martin”, the villain in a low-brow children’s television program. Niles notices that every time he enters a room in his enormous apartment, a new door exists in a different location on the wall. He pays the phenomenon no mind until multiple copies of himself start pouring from the doors.
Frasier donates aggressively - even violently - to charity. Martin volunteers at a soup kitchen but can’t stop eating the soup himself, and eventually finds his appearance becoming more disheveled and “homeless” with each bite. Niles sponsors a child overseas, but the child turns out to have surprisingly lavish tastes and quickly bankrupts him. Roz finds God and they begin dating. Daphne travels home to be with her ill mother in order to ensure she doesn’t recover.
In anticipation of upcoming promotional headshots being taken for his radio show, Frasier begins obsessively practicing a new condescending glare. Martin, unbeknownst to the household, takes up beekeeping in his bedroom. After taking a sewing class, Roz attempts to make her own dress, but the dress-form mannequin decides to keep it for itself. Niles, gawking in awe as a bus goes by bearing a picture of a horribly swollen, purple, bee-stung Frasier, absentmindedly strolls through a construction site and ends up knee deep in wet cement. After being stuck for several days, he resigns himself to setting up shop in the middle of the sidewalk and offering quick, efficient psychiatric advice to passersby in exchange for food or small amounts of money.
After a run-in with several “street-toughs” which amounted to little more than being lightly bumped into while crossing at a crowded intersection, an incensed Frasier appoints himself as the head of a community task force on civic decency. What begins as a noble cause quickly dissolves into nothing more than a vigilante group after Frasier gives an impassioned yet illogical speech to his members (“Why let the masses only go punished for the crimes they DO commit, when we all turn a blind eye to the crimes they DON’T commit! I for one am sick and tired of the hypocrisy, and I’m going to do something about it!”) which is met with cheers and righteous anger. After a few days, Frasier’s mob is national news due to a string of incidents involving thuggish beatings of ordinary middle class people going about their business.
One day, while waiting for a bus, Martin is swarmed by an Armani-clad gang of goons and beaten to a pulp. He sustains such severe injuries that half his face becomes nearly unrecognizable. When investigators observe security footage of the assault, they notice the group’s ringleader appears to be a crazed and wild-eyed Frasier, franticly directing the group to “bring justice to the masses, and remind them under whose boot heel they reside!”. Later that day, Frasier finds himself in jail with none of his sympathetic blue-blooded cronies, and backed into a corner by the other prisoners. Thinking fast, he jumps onto a bench and starts bellowing an impassioned “99%” speech, resulting in a jailhouse riot during which Frasier slips out undetected. Hours later, the door of the condo flies open violently and the exhausted psychiatrist stumbles inside; sleeves torn and face scratched and bruised. He slams the door and slumps triumphantly back against it with a grin. But his grin begins to fade as he looks up at the living room to see Martin calmly seated in his chair, cradling his old six-shooter straight at the doorway and forebodingly flipping a silver dollar with his other hand.
Niles is interviewed by the Seattle Times as an expert source for an article on mental health, but is so horribly misquoted by the journalist that he loses his medical license. Feeling he’s suffered one public humiliation too many, Dr. Crane releases his fear gas on an unsuspecting Seattle.
Martin begins to uncover evidence that an oversized phantasmal Jack Russell terrier has been stalking and killing off members of his bloodline dating back to the 17th century, causing him to quickly develop an extreme paranoia of Eddie. He insists Niles and Daphne look after Eddie for the weekend by making the excuse that he’ll be entertaining a lady-friend who is allergic to dogs. When Niles turns up dead and covered with bloody bite marks around his heels, Martin’s suspicions are confirmed, but Eddie’s whereabouts are now unknown.
Frasier once again reaches the second spot in the talk radio ratings and decides that his show would “tower head and shoulders above the frail and intellectually barren competition” if only his callers weren’t dragging him down. He abruptly drops the call-in concept of the show, instead opting for a three-hour interview format where friends, family, colleagues and meager celebrity guests reluctantly ask him flattering questions that Frasier prepares himself.
Martin, Roz and Daphne begin a city wide hound-hunt for the missing Eddie, and spend weeks following a grim trail of disembowelled homeless men. As the trail starts to go cold, Roz returns to work to find Bulldog in Frasier’s usual timeslot. When she confronts Kenny, he informs her that the newly reformatted Dr. Crane show was taken off the air weeks ago after ratings immediately hit rock bottom… and no one has seen Frasier since.
Back at the condo and all alone, Martin is unable to sleep in the early hours of the morning. Just as he starts drifting off, he hears the patter of tiny paws coming down the hallway to his door, and then watches in horror as the shadow of some nameless monstrosity casts itself across his bedroom wall.
The credits theme plays over a scene of Roz heading down into the KACL archives to retrieve a few tapes, where she finds a bearded and foul-smelling Frasier calmly and demurely answering silent questions from a stack of boxes with a makeshift mop-wig and crudely scribbled-on face.